Guthrie is a somewhat small city located in the state of Oklahoma. With a population of 11,191 people and seven associated neighborhoods, Guthrie is the 43rd largest community in Oklahoma.

Telecommuters are a relatively large percentage of the workforce: 7.70% of people work from home. While this number may seem small overall, as a fraction of the total workforce it is high relative to the nation. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

The citizens of Guthrie are slightly better educated than the national average of 21.84% for all cities and towns, with 22.81% of adults in Guthrie having a bachelor's degree or advanced degree.

The per capita income in Guthrie in 2022 was $27,297, which is upper middle income relative to Oklahoma, and lower middle income relative to the rest of the US. This equates to an annual income of $109,188 for a family of four. However, Guthrie contains both very wealthy and poor people as well.

Guthrie is a very ethnically-diverse city. The people who call Guthrie home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Guthrie residents report their race to be White, followed by Black or African-American. Important ancestries of people in Guthrie include Irish, German, English, Scottish, and French.

The most common language spoken in Guthrie is English. Other important languages spoken here include Spanish and Chinese.