Port St. Lucie is a relatively large coastal city (i.e. on the ocean, a bay, or inlet) located in the state of Florida. With a population of 231,790 people and 40 associated neighborhoods, Port St. Lucie is the seventh largest community in Florida. Much of the housing stock in Port St. Lucie was built relatively recently. The construction of new real estate can often be taken as an indication that the local Port St. Lucie economy is robust, and that jobs or other amenities are attracting an influx of new residents. This seems to be the case in Port St. Lucie, where the median household income is $75,040.00.

Also of interest is that Port St. Lucie has more people living here who work in computers and math than 95% of the places in the US.

Telecommuters are a relatively large percentage of the workforce: 8.96% of people work from home. While this number may seem small overall, as a fraction of the total workforce it is high relative to the nation. These workers are often telecommuters who work in knowledge-based, white-collar professions. For example, Silicon Valley has large numbers of people who telecommute. Other at-home workers may be self-employed people who operate small businesses out of their homes.

Port St. Lucie is also nautical, which means that parts of it are somewhat historic and touch the ocean or tidal bodies of water, such as inlets and bays. Such areas are often places that visitors and locals go for waterfront activities or taking in the scenery.

In Port St. Lucie, however, the average commute to work is quite long. On average, people spend 30.74 minutes each day getting to work, which is significantly higher than the national average.

The overall education level of Port St. Lucie is somewhat higher than in the average US city of 21.84%: 26.18% of adults 25 and older in the city have at least a bachelor's degree.

The per capita income in Port St. Lucie in 2018 was $35,301, which is middle income relative to Florida, and upper middle income relative to the rest of the US. This equates to an annual income of $141,204 for a family of four. However, Port St. Lucie contains both very wealthy and poor people as well.

Port St. Lucie is an extremely ethnically-diverse city. The people who call Port St. Lucie home describe themselves as belonging to a variety of racial and ethnic groups. The greatest number of Port St. Lucie residents report their race to be White, followed by Black or African-American. Port St. Lucie also has a sizeable Hispanic population (people of Hispanic origin can be of any race). People of Hispanic or Latino origin account for 22.88% of the city’s residents. Important ancestries of people in Port St. Lucie include Irish, Italian, German, English, and Haitian.

Foreign born people are also an important part of Port St. Lucie's cultural character, accounting for 19.52% of the city’s population.

The most common language spoken in Port St. Lucie is English. Other important languages spoken here include Spanish and French.